Simple POD. IOTL she died at the age of 35 due to either consumption or childbirth complications, having been Holy Roman Empress, Queen consort of Italy, Spain and the Romans and Lady of the Netherlands for years and regent of Spain due to her husband's frequent traveling. She was responsible for Spain's independence of imperial policies and thriving economy throughout her queenship. Upon her death, her devastated husband spent the rest of his life mourning for her. But what if he never needed to do this? What if she lived longer than him, dying in the 1560s? What effect would this have on her children and her domains?