Tudor-Habsburg-Valois joined empire - A TL

1516: Katherine of Aragon quickly recovers from a strenuous pregnancy. She has given birth to healthy twins, Henry and Mary, and she and her husband are overjoyed and utterly doting parents. Meanwhile, her young nephew Charles V marries his cousin Isabella of Portugal during that year's Christmas, and across the ocean, Francis I is expecting his second child with his wife, Claude.
 
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1518: Francis and Claude have their first son, Francis. While Henry VIII and Katherine have their final child, a daughter named Elizabeth.
 
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1523: Charles and Isabella have their first children, twin sons named Charles and Philip. While Francis and Claude have their final child, a daughter named Margaret. Mary, oldest daughter to Henry and Katherine, is betrothed to the oldest son of Francis and Claude who is also named Francis. The French princess, Margaret is betrothed to Charles, the older son of Charles and Isabella.
 
1527: Charles and Isabella have their third son, John. Henry, Prince of Wales is betrothed to Maria, Duchess of Viseu who was also his cousin.
 
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1529: Katherine of Aragon dies of heart cancer. Her widowed husband, Henry remarries to her niece Mary, dowager queen of Hungary and Bohemia. That same year, Maria Duchess of Viseu arrives in England to marry the prince of Wales.
 
1531: Henry VIII and Mary of Austria have triplets together: Owen Duke of York, Edmund Duke of Somerset and Edward Duke of Richmond. Unfortunately this difficult childbirth results in Mary becoming unable to have any more children. That same year, his oldest daughter, also named Mary, goes to France to marry Francis Duke of Brittany.
 
1533: Mary of Austria passes away from a heart attack, bequeathing all she had to her husband. Henry VIII remarries to his wife's maid, Anne Boleyn, but Anne's passionate reformist stance on religion soon raises a lot of eyebrows. Charlotte of France was supposed to be married to James V of Scotland, but he fell for her sister Madeleine instead. So, she married Antoine de Bourbon. Anne Boleyn gives birth to a daughter named Margaret, after Henry's sister, and the young princess is betrothed to Emmanuel Philibert, Duke of Savoy.
 
1534: Mary Tudor, daughter of Henry VIII, gives birth to her first son, Louis, with Francis III Duke of Brittany. Anne Boleyn bears Henry a son, named Thomas after her father. While Eleanor and Francis have a daughter, Francoise.
 
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1536: Anne Boleyn bears Henry another son, named George after her brother. She dies from childbirth complications and Henry remarries to her maid, Jane Seymour. A month later, Isabella of Portugal and Maria, Duchess of Viseu both announce pregnancies.
 
1537: Maria, Princess of Wales has a daughter, Eleanor, with Henry, Prince of Wales. While Isabella of Portugal also has a daughter with Charles, named Joanna.
 
1538: Maria, Princess of Wales bears a son, also named Henry. He is created the Duke of Exeter and Clarence and his birth is celebrated throughout England. He is betrothed to his cousin, Joanna.
 
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