Descendants of Isabella and Ferdinand:
1. Isabella (2 Oct 1470-19 Jan 1506), Princess of Asturias (1497-1504), Queen consort of Portugal (1497-1506), Queen of Castile (1504-1506). She married first Afonso, Prince of Portugal, but after his death she married his uncle King Emanuel I of Portugal.
1. Miguel (23 Aug 1498-5 April 1543), Prince of Portugal (from birth), Prince of Asturias (1504-1506), King of Portugal (1521-1543), King of Castile (1506-1543), King of Aragon (1516-1543).
2. miscarriage, 1500
3. miscarriage, 1505
2. Son miscarried on 31 May 1475 in Cebreros
3. John (30 Jun 1478-4 Oct 1497), Prince of Asturias (1478-1497). He married Margaret of Habsburg (daughter of Emperor Maximilian I). He died of tuberculosis and his posthumous child with Margaret was stillborn.
4. Joanna (6 Nov 1479-12 Oct 1506), married Philip IV, Duke of Burgundy (d. 25 Sept 1506) (son of the Emperor Maximilian I). She and her husband died of typhoid fever, less than a month apart.
1. Eleanor (1498-1558), married in 1517, Sigismund I of Poland and Lithuania, after a childhood betrothal to Prince William of England, who died young.
2. Charles (1500-1515), Duke of Burgundy (1506-1515)
3. Isabella (1501-1553), married in 1515, Louis II of Hungary and Bohemia; no surviving issue.
4. Ferdinand (1503-1564), Holy Roman Emperor (1525-1564) married in 1521, Anna of Bohemia and Hungary and had children.
5. Mary (1505), died shortly after birth.
She was pregnant with her sixth child at the time of her death.
5. Maria (29 Jun 1482-7 Mar 1527). She married Manuel (Isabella's widower) 1508, and had issue.
6. Stillborn Daughter, twin of Maria. Born 1 July 1482 at dawn.
7. Catalina (16 Dec 1485-1536), later known Catherine of Aragon, queen of England. She married Arthur, Prince of Wales, son of and heir to King Henry VII of England.
1. William Theodore (1503-?? before 1516)
2. Dafydd (1506-1562), King of England (as David I) (1533-1562)
3. Elizabeth (1508-??)
others?